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Addiction Treatment: Alternatives to Methadone

Posted on :  July 22nd, 2015  |  By :  towardsrecovery

As the fight against addiction continues, researchers are always looking for new ways to end this growing problem. Right now, methadone is one of the most commonly used treatment protocols for deathly addictions to heroin and other opioids. This treatment remains effective, which is why it is repeatedly used, but researchers would like to find another one that can work for those who prefer to avoid methadone.

Treating drug addiction with other drugs creates chemical reactions with the chemical reactions of the drugs users are abusing. In some cases, those treatment drugs can cause negative effects on the body. One is Antabuse, which causes those who are fighting alcohol addiction to become sick to their stomachs if they imbibe. By causing the user to want to vomit while taking Antabuse and drinking alcohol, the road to recovery is success because the mind associates alcohol with the feeling of vomiting. Now, researchers who are searching for working medications for heroin addicts have found a drug called Naloxone. In a few studies, researchers have seen interesting outcomes.

Naxolene appears to work by getting involved with the receptor in the brain that is tied to heroin addiction. This receptor is called the Toll-like receptor 4 (TLR4). Naxolene also seems to work by blocking cocaine, too. The TLR4 receptor is responsible for creating the sense of euphoria that comes with using opioids. The receptor appears to make a response that is known as pro-inflammatory, which is an unhealthy reaction that can cause problems like fevers, nausea, inflammation, and tissue loss. When it comes to opioid and cocaine addiction, this pro-inflammation seems like a reward to the human brain, which is why the drugs are so addicting.

When Naxolene is tested, researchers and scientists noticed that opioids were unable to connect to the receptor. This deadens the effects of the drug, so that the user no longer experiences the rewards like euphoria and stoppage of pain. If the drug no longer works, the user should no longer want it; this is the goal of researchers.

The addict’s brain enjoys the feeling from heroin or cocaine use. They often call the experience a “rush” and this occurs when the TLR4 is activated with the molecules of the drug. Once that first rush occurs, the user has no idea that rush will be the best one that he or she will experience. Then, the user tries to recreate the perfect rush with every other use, but to avail. The user will need more drugs to get close. This is what is known as tolerance as the user builds up something like an immunity to the drug. The desire is that the user will eventually stop because of the lack of rush, but many users just keep abusing with the hopes that a rush will occur. Eventually, users overdose trying to get high when their brains will no longer allow it. With Naxolene, the users will be able to stop using before they get to the point of desperation that eventually results in death by overdose.

With researchers finding that TLR4 is responsible not only for the rush from opioids, but also from cocaine, they are closer to making Naxolene a reality for treatment centers. Researchers are hoping to be able to use Naxolene with other addictive substances like methamphetamine and with alcohol. They are hoping that the discovery will be easy to find so that they can simply use Naxolene or another substance that will block a receptor like TLR4. Maybe the discoveries relating to Naxolene will help researchers find the solution to every danger addiction.

If you have any questions or you want to visit Towards Recovery Clinic, please contact us at our head office at 905-527-2042.

Who We Serve ?

  • Individuals using/abusing street narcotics (e.g. heroin).
  • Patients abusing prescription narcotics(i.e., Codeine, Talwin, Percocet/Percodan, Dilaudid, Morphine or Demerol, et cetera).
  • Individuals displaying any of the following behaviours: Compulsive drug use or drug seeking/craving.
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